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terminal sialic acid residues  (Thermo Fisher)


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    Structured Review

    Thermo Fisher terminal sialic acid residues
    Examples of bnAb recognition of glycans. A. The light chain (dark gray) of 3BNC117 (PDB 5V8L), a CD4bs-directed bnAb, interacts primarily with the core GlcNAc moieties (blue) at the base of the glycan and less with the branched Man glycans (green). Note that the glycans are only resolved to Man-6 with the <t>terminal</t> branching glycans (indicated by arrows) disordered in the cryoEM map. B. The heavy chain (dark gray) of PGT128 (PDB 5ACO), an N332 supersite bnAb, interacts with extended Man-8 (shown) or Man-9 glycans. Because these glycan moieties interact strongly with the bnAb heavy (dark gray) and light (light gray) chains, they are typically well resolved in crystallographic or cryoEM maps. In fact, PGT128 binds high mannose so well that the structure of the Fab and Man-9 alone was solved by crystallography (PDB 3TV3) (103). Man-8 is resolved in the figure shown. C. The heavy chain (dark gray) of PGT151 (PDB 5FUU), a gp120/gp41 interface bnAb interacts with minimally a tri-antennary complex glycan. Glycan array binding data suggest that this N611 glycan may be contain terminal <t>sialic</t> <t>acid</t> <t>residues</t> (indicated by magenta *), but these were not resolved in the cryo-EM map. D. The heavy chain (dark gray) of PG16 (PDB 4DQO) interacts with a terminal sialic acid of a hybrid-type glycan at N173.
    Terminal Sialic Acid Residues, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 95/100, based on 199 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/terminal sialic acid residues/product/Thermo Fisher
    Average 95 stars, based on 199 article reviews
    terminal sialic acid residues - by Bioz Stars, 2026-02
    95/100 stars

    Images

    1) Product Images from "Structure and Immune Recognition of the HIV Glycan Shield"

    Article Title: Structure and Immune Recognition of the HIV Glycan Shield

    Journal: Annual review of biophysics

    doi: 10.1146/annurev-biophys-060414-034156

    Examples of bnAb recognition of glycans. A. The light chain (dark gray) of 3BNC117 (PDB 5V8L), a CD4bs-directed bnAb, interacts primarily with the core GlcNAc moieties (blue) at the base of the glycan and less with the branched Man glycans (green). Note that the glycans are only resolved to Man-6 with the terminal branching glycans (indicated by arrows) disordered in the cryoEM map. B. The heavy chain (dark gray) of PGT128 (PDB 5ACO), an N332 supersite bnAb, interacts with extended Man-8 (shown) or Man-9 glycans. Because these glycan moieties interact strongly with the bnAb heavy (dark gray) and light (light gray) chains, they are typically well resolved in crystallographic or cryoEM maps. In fact, PGT128 binds high mannose so well that the structure of the Fab and Man-9 alone was solved by crystallography (PDB 3TV3) (103). Man-8 is resolved in the figure shown. C. The heavy chain (dark gray) of PGT151 (PDB 5FUU), a gp120/gp41 interface bnAb interacts with minimally a tri-antennary complex glycan. Glycan array binding data suggest that this N611 glycan may be contain terminal sialic acid residues (indicated by magenta *), but these were not resolved in the cryo-EM map. D. The heavy chain (dark gray) of PG16 (PDB 4DQO) interacts with a terminal sialic acid of a hybrid-type glycan at N173.
    Figure Legend Snippet: Examples of bnAb recognition of glycans. A. The light chain (dark gray) of 3BNC117 (PDB 5V8L), a CD4bs-directed bnAb, interacts primarily with the core GlcNAc moieties (blue) at the base of the glycan and less with the branched Man glycans (green). Note that the glycans are only resolved to Man-6 with the terminal branching glycans (indicated by arrows) disordered in the cryoEM map. B. The heavy chain (dark gray) of PGT128 (PDB 5ACO), an N332 supersite bnAb, interacts with extended Man-8 (shown) or Man-9 glycans. Because these glycan moieties interact strongly with the bnAb heavy (dark gray) and light (light gray) chains, they are typically well resolved in crystallographic or cryoEM maps. In fact, PGT128 binds high mannose so well that the structure of the Fab and Man-9 alone was solved by crystallography (PDB 3TV3) (103). Man-8 is resolved in the figure shown. C. The heavy chain (dark gray) of PGT151 (PDB 5FUU), a gp120/gp41 interface bnAb interacts with minimally a tri-antennary complex glycan. Glycan array binding data suggest that this N611 glycan may be contain terminal sialic acid residues (indicated by magenta *), but these were not resolved in the cryo-EM map. D. The heavy chain (dark gray) of PG16 (PDB 4DQO) interacts with a terminal sialic acid of a hybrid-type glycan at N173.

    Techniques Used: Binding Assay, Cryo-EM Sample Prep



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    terminal sialic acid residues  (Thermo Fisher)
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    Thermo Fisher terminal sialic acid residues
    Examples of bnAb recognition of glycans. A. The light chain (dark gray) of 3BNC117 (PDB 5V8L), a CD4bs-directed bnAb, interacts primarily with the core GlcNAc moieties (blue) at the base of the glycan and less with the branched Man glycans (green). Note that the glycans are only resolved to Man-6 with the <t>terminal</t> branching glycans (indicated by arrows) disordered in the cryoEM map. B. The heavy chain (dark gray) of PGT128 (PDB 5ACO), an N332 supersite bnAb, interacts with extended Man-8 (shown) or Man-9 glycans. Because these glycan moieties interact strongly with the bnAb heavy (dark gray) and light (light gray) chains, they are typically well resolved in crystallographic or cryoEM maps. In fact, PGT128 binds high mannose so well that the structure of the Fab and Man-9 alone was solved by crystallography (PDB 3TV3) (103). Man-8 is resolved in the figure shown. C. The heavy chain (dark gray) of PGT151 (PDB 5FUU), a gp120/gp41 interface bnAb interacts with minimally a tri-antennary complex glycan. Glycan array binding data suggest that this N611 glycan may be contain terminal <t>sialic</t> <t>acid</t> <t>residues</t> (indicated by magenta *), but these were not resolved in the cryo-EM map. D. The heavy chain (dark gray) of PG16 (PDB 4DQO) interacts with a terminal sialic acid of a hybrid-type glycan at N173.
    Terminal Sialic Acid Residues, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/terminal sialic acid residues/product/Thermo Fisher
    Average 95 stars, based on 1 article reviews
    terminal sialic acid residues - by Bioz Stars, 2026-02
    95/100 stars
    		  Buy from Supplier
    terminal sialic acid residues  (SAS institute)
    90
    SAS institute terminal sialic acid residues
    Examples of bnAb recognition of glycans. A. The light chain (dark gray) of 3BNC117 (PDB 5V8L), a CD4bs-directed bnAb, interacts primarily with the core GlcNAc moieties (blue) at the base of the glycan and less with the branched Man glycans (green). Note that the glycans are only resolved to Man-6 with the <t>terminal</t> branching glycans (indicated by arrows) disordered in the cryoEM map. B. The heavy chain (dark gray) of PGT128 (PDB 5ACO), an N332 supersite bnAb, interacts with extended Man-8 (shown) or Man-9 glycans. Because these glycan moieties interact strongly with the bnAb heavy (dark gray) and light (light gray) chains, they are typically well resolved in crystallographic or cryoEM maps. In fact, PGT128 binds high mannose so well that the structure of the Fab and Man-9 alone was solved by crystallography (PDB 3TV3) (103). Man-8 is resolved in the figure shown. C. The heavy chain (dark gray) of PGT151 (PDB 5FUU), a gp120/gp41 interface bnAb interacts with minimally a tri-antennary complex glycan. Glycan array binding data suggest that this N611 glycan may be contain terminal <t>sialic</t> <t>acid</t> <t>residues</t> (indicated by magenta *), but these were not resolved in the cryo-EM map. D. The heavy chain (dark gray) of PG16 (PDB 4DQO) interacts with a terminal sialic acid of a hybrid-type glycan at N173.
    Terminal Sialic Acid Residues, supplied by SAS institute, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/terminal sialic acid residues/product/SAS institute
    Average 90 stars, based on 1 article reviews
    terminal sialic acid residues - by Bioz Stars, 2026-02
    90/100 stars
    		  Buy from Supplier

    Image Search Results


    Examples of bnAb recognition of glycans. A. The light chain (dark gray) of 3BNC117 (PDB 5V8L), a CD4bs-directed bnAb, interacts primarily with the core GlcNAc moieties (blue) at the base of the glycan and less with the branched Man glycans (green). Note that the glycans are only resolved to Man-6 with the terminal branching glycans (indicated by arrows) disordered in the cryoEM map. B. The heavy chain (dark gray) of PGT128 (PDB 5ACO), an N332 supersite bnAb, interacts with extended Man-8 (shown) or Man-9 glycans. Because these glycan moieties interact strongly with the bnAb heavy (dark gray) and light (light gray) chains, they are typically well resolved in crystallographic or cryoEM maps. In fact, PGT128 binds high mannose so well that the structure of the Fab and Man-9 alone was solved by crystallography (PDB 3TV3) (103). Man-8 is resolved in the figure shown. C. The heavy chain (dark gray) of PGT151 (PDB 5FUU), a gp120/gp41 interface bnAb interacts with minimally a tri-antennary complex glycan. Glycan array binding data suggest that this N611 glycan may be contain terminal sialic acid residues (indicated by magenta *), but these were not resolved in the cryo-EM map. D. The heavy chain (dark gray) of PG16 (PDB 4DQO) interacts with a terminal sialic acid of a hybrid-type glycan at N173.

    Journal: Annual review of biophysics

    Article Title: Structure and Immune Recognition of the HIV Glycan Shield

    doi: 10.1146/annurev-biophys-060414-034156

    Figure Lengend Snippet: Examples of bnAb recognition of glycans. A. The light chain (dark gray) of 3BNC117 (PDB 5V8L), a CD4bs-directed bnAb, interacts primarily with the core GlcNAc moieties (blue) at the base of the glycan and less with the branched Man glycans (green). Note that the glycans are only resolved to Man-6 with the terminal branching glycans (indicated by arrows) disordered in the cryoEM map. B. The heavy chain (dark gray) of PGT128 (PDB 5ACO), an N332 supersite bnAb, interacts with extended Man-8 (shown) or Man-9 glycans. Because these glycan moieties interact strongly with the bnAb heavy (dark gray) and light (light gray) chains, they are typically well resolved in crystallographic or cryoEM maps. In fact, PGT128 binds high mannose so well that the structure of the Fab and Man-9 alone was solved by crystallography (PDB 3TV3) (103). Man-8 is resolved in the figure shown. C. The heavy chain (dark gray) of PGT151 (PDB 5FUU), a gp120/gp41 interface bnAb interacts with minimally a tri-antennary complex glycan. Glycan array binding data suggest that this N611 glycan may be contain terminal sialic acid residues (indicated by magenta *), but these were not resolved in the cryo-EM map. D. The heavy chain (dark gray) of PG16 (PDB 4DQO) interacts with a terminal sialic acid of a hybrid-type glycan at N173.

    Article Snippet: Glycan array binding data suggest that this N611 glycan may be contain terminal sialic acid residues (indicated by magenta *), but these were not resolved in the cryo-EM map.

    Techniques: Binding Assay, Cryo-EM Sample Prep